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Nr0b2 Gene Detail
Summary
  • Symbol
    Nr0b2
  • Name
    nuclear receptor subfamily 0, group B, member 2
  • Synonyms
    SHP, SHP-1, small heterodimer partner
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346344
    NCBI Gene: 23957
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:133280687-133283847 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 66.25 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    187 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346344
 protein coding gene Chr4:133280687-133283997 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028898
 protein coding gene Chr4:135818900-135822043 (+)
A/J MGP_AJ_G0028857
 protein coding gene Chr4:130130394-130133525 (+)
AKR/J MGP_AKRJ_G0028810
 protein coding gene Chr4:133828999-133832135 (+)
BALB/cJ MGP_BALBcJ_G0028880
 protein coding gene Chr4:130762200-130765368 (+)
C3H/HeJ MGP_C3HHeJ_G0028594
 protein coding gene Chr4:134080209-134083340 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029322
 protein coding gene Chr4:140691628-140694796 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026593
 protein coding gene Chr4:123200866-123203825 (+)
CAST/EiJ MGP_CASTEiJ_G0028027
 protein coding gene Chr4:132197679-132200755 (+)
CBA/J MGP_CBAJ_G0028560
 protein coding gene Chr4:144376917-144380048 (+)
DBA/2J MGP_DBA2J_G0028709
 protein coding gene Chr4:130549799-130553013 (+)
FVB/NJ MGP_FVBNJ_G0028676
 protein coding gene Chr4:129430020-129433481 (+)
LP/J MGP_LPJ_G0028810
 protein coding gene Chr4:135932922-135936065 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028702
 protein coding gene Chr4:148884032-148887278 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029360
 protein coding gene Chr4:134252984-134256152 (+)
PWK/PhJ MGP_PWKPhJ_G0027748
 protein coding gene Chr4:127267959-127271162 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027574
 protein coding gene Chr4:130083214-130086672 (+)
WSB/EiJ MGP_WSBEiJ_G0028107
 protein coding gene Chr4:134431403-134434522 (+)



Homology
more
  • Human Ortholog
    NR0B2, nuclear receptor subfamily 0 group B member 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NR0B2, nuclear receptor subfamily 0 group B member 2
  • Synonyms
    SHP, SHP1
  • Links
    NCBI Gene ID: 8431
    neXtProt AC: NX_Q15466
    UniProt: Q15466

  • Chr Location
    1p36.11; chr1:26911489-26913975 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human NR0B2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 6 alleles in 5 genetic backgrounds
    3 phenotypes from multigenic genotypes
    75 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation are viable and fertile and exhibit no major defects in cholesterol metabolism under normal conditions. Under high cholesterol and cholic acid or iodine-deficient diets, mice exhibit decreased lipid levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    882
  • Tissues
    157
  • cDNA Data
    20
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037583 Ensembl Gene Model | MGI Sequence Detail 3161 C57BL/6J ±  kb
    transcript ENSMUST00000042706 Ensembl | MGI Sequence Detail 1132 Not Applicable  
    polypeptide ENSMUSP00000039175 Ensembl | MGI Sequence Detail 260 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 20
      Primer pair 3
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 166
      Developmental Gene Expression 18
      Gene Ontology 11
      Phenotypes 75
    • Earliest
      J:33440 Seol W, et al., An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors. Science. 1996 May 31;272(5266):1336-9
    • Latest
      J:350501 Vidana Gamage HE, et al., NR0B2 re-educates myeloid immune cells to reduce regulatory T cell expansion and progression of breast and other solid tumors. Cancer Lett. 2024 Jun 20;597:217042
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory